• Infection caused by Zika virus, an arthropod-borne flavivirus transmitted by Aedes mosquitoes. Sexual transmission has also been confirmed.
  • In the US, local transmission by mosquitoes has been reported in Florida and Texas.
  • Majority of patients are asymptomatic; however, about 20% of infections result in a mild, self-limited illness with fever, rash, arthralgia, and conjunctivitis.
  • There is strong scientific consensus that Zika virus is a cause of microcephaly and other congenital abnormalities. The range of abnormalities seen and the likely causal link to the virus suggest a new congenital syndrome.
  • Guillain-Barre syndrome and other neurologic disorders are strongly associated with, and suspected to be caused by, Zika virus, but the link is unproven and studies are ongoing, including to elucidate a possible mechanism.
  • Treatment of symptomatic infection is supportive and there are no specific antiviral therapies at this time.
  • Prevention of mosquito bites through individual and public health measures is important to prevent infections.
  • Pregnant women are advised not to travel to areas with Zika virus infection risk. Women who may have been exposed to infection during pregnancy are advised to have molecular and/or serologic testing and fetal/newborn monitoring.
  • Zika purified inactivated virus (ZPIV) vaccine has started clinical trials to test safety and efficacy.

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