• A human papilloma virus (HPV)-related malignancy, preventable by HPV vaccination, screening, and treatment of high-grade dysplasia.
  • Pap smear screening followed by colposcopy may diagnose preinvasive disease.
  • Locally advanced disease may present with bleeding, discharge, pain, or obstructive uropathy.
  • Staging is clinical, and does not incorporate lymph node evaluation or imaging results, but increasingly uses MRI to evaluate local extent of disease, and PET to screen for nodal and distant metastases.
  • For microinvasive disease, treatment with conization is recommended.
  • For early stage invasive disease, surgery is recommended.
  • For locally advanced disease, chemoradiation therapy is significantly superior to radiation therapy alone.

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