• Cancer that develops in any portion of the stomach and may spread to other organs.
  • Presents with weight loss and abdominal pain, although patients with proximal or gastroesophageal junction tumors may present with dysphagia.
  • Upper GI endoscopy with biopsy demonstrating carcinoma is required to confirm the diagnosis. Staging based on imaging is required.
  • Early-stage disease is treated with surgery alone.
  • Locally advanced disease should undergo surgery followed by postoperative chemoradiation, or chemotherapy before and after surgery.
  • Metastatic disease is treated with chemotherapy or chemoradiation and supportive care measures.
  • Common complications are gastric bleeding and obstruction.

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