- Infection with HSV-1 or HSV-2 can cause oral, genital, and ocular ulcers. Most people have unrecognized disease.
- Symptoms of genital herpes range from asymptomatic to tingling and burning without lesions, to recurrent genital ulcerations.
- Symptoms of herpes labialis include tingling and burning followed by development of vesicular then ulcerative lesions involving the oropharynx and perioral mucosa.
- Acyclovir, famciclovir, and valacyclovir are effective at shortening the duration and severity of an outbreak.
- Daily suppressive therapy reduces recurrences by 80% and reduces transmission risk by approximately 50%.
- HSV type-specific antibody tests are used to diagnose infection with or without lesions and distinguish between type 1 and 2.