• Common childhood viral infection caused most often by coxsackievirus A16.
  • Usually a mild illness characterized by low-grade fever, painful oral ulcers, and vesicles on palms of the hands and soles of the feet.
  • Infection typically resolves spontaneously within 10 to 14 days, and treatment is mainly supportive.
  • In East and Southeast Asian countries, enterovirus 71 (EV71) is responsible for a more severe version of the disease with serious complications; however, this is uncommon in the US and Europe.

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