Summary

  • Nonalcoholic hepatic steatosis, or nonalcoholic fatty liver disease, is the most common cause of chronic liver disease in the Western world.
  • It is projected to become a leading indication for liver transplantation, superseding hepatitis C.
  • The diagnosis of hepatic steatosis is based on exclusion of other etiologies, such as alcohol use, along with histology.
  • Associated with obesity and features of the metabolic syndrome in most cases. May progress to steatohepatitis and end-stage liver disease.
  • There are no currently recommended drug treatments. Lifestyle modification remains the first-line therapy.

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